Slattery M L, Edwards S L, Boucher K M, Anderson K, Caan B J
University of Utah, Department of Family and Preventive Medicine, Health Research Center, Salt Lake City 84108, USA.
Am J Epidemiol. 1999 Oct 15;150(8):869-77. doi: 10.1093/oxfordjournals.aje.a010092.
Studies of the etiology of colon cancer indicate that it is strongly associated with diet and lifestyle factors. The authors use data from a population-based study conducted in northern California, Utah, and Minnesota in 1991-1995 to determine lifestyle patterns and their association with colon cancer. Data obtained from 1,993 cases and 2,410 controls were grouped by using factor analyses to describe various aspects of lifestyle patterns. The first five lifestyle patterns for both men and women loaded heavily on dietary variables and were labeled: "Western," "moderation," "calcium/low-fat dairy;" "meat and mutagens," and "nibblers, smoking, and coffee." Other important lifestyle patterns that emerged were labeled "body size," "medication and supplementation," "alcohol," and "physical activity." Among both men and women, the lifestyle characterized by high levels of physical activity was the most marked lifestyle associated with colon cancer (odds ratios = 0.42, 95% confidence interval: 0.32, 0.55 and odds ratio = 0.52, 95% confidence interval: 0.39, 0.69, for men and women, respectively) followed by medication and supplementation (odds ratio = 1.68, 95% confidence interval: 1.29, 2.18 and odds ratio = 1.63, 95% CI 1.23, 2.16, respectively). Other lifestyles that were associated with colon cancer were the Western lifestyle, the lifestyle characterized by large body size, and the one characterized by calcium and low-fat dairy. Different lifestyle patterns appear to have age- and tumor site-specific associations.
结肠癌病因学研究表明，它与饮食和生活方式因素密切相关。作者利用1991年至1995年在加利福尼亚州北部、犹他州和明尼苏达州进行的一项基于人群的研究数据，来确定生活方式模式及其与结肠癌的关联。通过因子分析对从1993例病例和2410名对照中获得的数据进行分组，以描述生活方式模式的各个方面。男性和女性的前五种生活方式模式在饮食变量上负荷较重，分别被标记为：“西方型”、“适度型”、“钙/低脂乳制品型”、“肉类和诱变剂型”以及“零食、吸烟和咖啡型”。其他出现的重要生活方式模式被标记为“体型”、“药物和补充剂”、“酒精”和“体育活动”。在男性和女性中，以高水平体育活动为特征的生活方式是与结肠癌关联最显著的生活方式（男性的优势比=0.42，95%置信区间：0.32，0.
