Jang Han Byul, Choi Min-Kyu, Kang Jae Heon, Park Sang Ick, Lee Hye-Ja
1Center for Biomedical Science, Korea National Institute of Health, Cheongju, Chungcheongbuk-do Republic of Korea.
2Department of Family Medicine, Gangnam Hallym Sacred Heart Hospital, Hallym University, Seoul, Republic of Korea.
BMC Nutr. 2017 Mar 4;3:20. doi: 10.1186/s40795-016-0125-z. eCollection 2017.
The gut microbiota has emerged as an important environmental factor associated with obesity, type 2 diabetes, and cardiovascular disease, through its interactions with dietary factors. Therefore, we analyzed the composition of the fecal microbiota and levels of biochemical markers related to metabolic disease according to dietary pattern in Korean adolescents.
We collected fecal samples from 112 student subjects aged 13-16 years with sufficient information available regarding clinical biomarkers and diet, and performed 16S rRNA targeted gene sequencing.
Regarding bacterial composition according to taxonomic rank, we found that traditional dietary patterns enriched in plant-based and fermented foods were associated with higher proportions of () and (-) and a lower proportion of () relative to modified Western dietary patterns (a greater proportion of animal-based foods). Specifically, the proportion of () was associated with intake of plant-based nutrients such as fiber; however, that of () was negatively associated with these factors. Additionally, we observed that the increase of () and decrease of () and had a higher risk of obesity. We also found that the traditional dietary pattern was negatively associated with general and central adiposity and levels of clinical biomarkers, including AST, ALT, total cholesterol, triglyceride, hs-CRP, insulin, and HOMA-IR, whereas the positive associations were found for a modified Western dietary pattern.
These findings suggest that the gut microbiota composition differs markedly according to dietary intake and suggest a role for diet in promoting a gut microbiome associated with the pathogenesis of metabolic disease.
肠道微生物群已成为与肥胖、2型糖尿病和心血管疾病相关的重要环境因素，通过其与饮食因素的相互作用。因此，我们根据韩国青少年的饮食模式分析了粪便微生物群的组成以及与代谢疾病相关的生化标志物水平。
我们从112名年龄在13 - 16岁的学生受试者中收集粪便样本，这些受试者有关于临床生物标志物和饮食的充分可用信息，并进行了16S rRNA靶向基因测序。
关于根据分类等级的细菌组成，我们发现富含植物性和发酵食品的传统饮食模式与（）和（）的比例较高以及相对于改良西方饮食模式（动物性食品比例更高）的（）比例较低有关。具体而言，（）的比例与纤维等植物性营养素的摄入量有关；然而，（）的比例与这些因素呈负相关。此外，我们观察到（）的增加以及（）和（）的减少有更高的肥胖风险。我们还发现传统饮食模式与总体和中心性肥胖以及临床生物标志物水平呈负相关，这些生物标志物包括AST、ALT、总胆固醇、甘油三酯、hs - CRP、胰岛素和HOMA - IR，而改良西方饮食模式则呈正相关。
这些发现表明肠道微生物群组成根据饮食摄入量有显著差异，并表明饮食在促进与代谢疾病发病机制相关的肠道微生物群方面的作用。
