Parashos A J
Behav Neuropsychiatry. 1976;8(1-12):83-6.
The effects of the psilocybin, a psychomimetic substance, on mental junctioning were investigated in normal volunteers as well as in schizophrenics. The disturbances induced constitute a psychoneurotoxic syndrome--"a state of drunkenness"--of about four hours duration which develops in three distinct phases. The basic mental symptoms of this syndrome consist of disturbances of the apperception, sensory perception and emotion. A moderate impairment of egofunctioning or reality appraisal and an inability to integrate different mental processes are observed. The psychomotor behavior is mainly harmonized to the prevailing emotional state and to the experiences caused by perceptual alterations, in a lesser degree. These changes, according to our observations, are more severe and more "psychotic-like" in schizophrenics rather than in normals. Psychopathological analysis of these changes proves that the whole syndrome cannot be considered as related to the spontaneously triggered functional psychoses or to the organic ones and, therefore, the term "model-psychosis" according to our opinion, is unsatisfactory.
对致幻物质裸盖菇素在正常志愿者和精神分裂症患者中对精神连接的影响进行了研究。所诱发的紊乱构成一种精神神经毒性综合征——“醉酒状态”——持续约四个小时，分为三个不同阶段发展。该综合征的基本精神症状包括统觉、感觉知觉和情感障碍。观察到自我功能或现实评估有中度损害，且无法整合不同的心理过程。精神运动行为主要与占主导地位的情绪状态以及在较小程度上与感知改变所引起的体验相协调。根据我们的观察，这些变化在精神分裂症患者中比在正常人中更为严重且更具“类精神病性”。对这些变化的精神病理学分析证明，整个综合征不能被视为与自发引发的功能性精神病或器质性精神病相关，因此，我们认为“模型精神病”这一术语并不令人满意。
