Llorens O, Perez J J, Palomer A, Mauleon D
Dept. d'Enginyeria Quimica, UPC, ETSEIB, Barcelona, Spain.
Bioorg Med Chem Lett. 1999 Oct 4;9(19):2779-84. doi: 10.1016/s0960-894x(99)00481-3.
Molecular modeling studies performed on the two cyclooxygenase (COX) isozymes suggest that the cavity at the mouth of the active site on the membrane domain that may act as an actual binding site of COX ligands. Actual docking of different inhibitors at this site provides a structural basis to explain the dynamics of COX inhibition.
对两种环氧化酶（COX）同工酶进行的分子建模研究表明，膜结构域活性位点开口处的腔可能是COX配体的实际结合位点。不同抑制剂在此位点的实际对接为解释COX抑制的动力学提供了结构基础。
