3-（3-苯基异恶唑-5-基）亚甲基-1-氮杂双环与乙酰胆碱受体的结合亲和力。
Binding affinities of 3-(3-phenylisoxazol-5-yl)methylidene-1-azabicycles to acetylcholine receptors.
作者信息
Choi K I, Cha J H, Cho Y S, Pae A N, Jin C, Yook J, Cheon H G, Jeong D, Kong J Y, Koh H Y
机构信息
Life Sciences Division, Korea Institute of Science and Technology, Seoul.
出版信息
Bioorg Med Chem Lett. 1999 Oct 4;9(19):2795-800. doi: 10.1016/s0960-894x(99)00477-1.
Abstract
A series of 3-(3-phenylisoxazol-5-yl)methylidene-1-azabicycles synthesized showed different binding characteristics to acetylcholine receptors depending on the substituents on the phenyl ring. Small polar substituents gave preferential binding affinity to nicotinic receptors, and large hydrophobic substituents to muscarinic receptors.
摘要
合成的一系列3-（3-苯基异恶唑-5-基）亚甲基-1-氮杂双环化合物根据苯环上的取代基不同，对乙酰胆碱受体表现出不同的结合特性。小的极性取代基对烟碱型受体具有优先结合亲和力，而大的疏水取代基对毒蕈碱型受体具有优先结合亲和力。
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