人巨细胞病毒蛋白酶的2-氯-3-取代-1,4-萘醌失活剂。
2-chloro-3-substituted-1,4-naphthoquinone inactivators of human cytomegalovirus protease.
作者信息
Ertl P, Cooper D, Allen G, Slater M J
机构信息
GlaxoWellcome Medicines Research Centre, Stevenage, UK.
出版信息
Bioorg Med Chem Lett. 1999 Oct 4;9(19):2863-6. doi: 10.1016/s0960-894x(99)00489-8.
Abstract
A random screening approach has identified 2-chloro-3-substituted-1,4-naphthoquinones as potent inactivators of HCMV protease. Enzyme inactivation is due to modification of Cys202. Two of the most potent compounds maintain activity against HCMV in a plaque reduction assay.
摘要
一种随机筛选方法已鉴定出2-氯-3-取代-1,4-萘醌是巨细胞病毒蛋白酶的有效失活剂。酶失活是由于半胱氨酸202的修饰。两种最有效的化合物在蚀斑减少试验中对巨细胞病毒保持活性。
Zotero 插件