Saloga J, Knop J
Department of Dermatology, University of Mainz, Langenbeckstr. 1, 55131 Mainz, Germany.
Eur J Dermatol. 1999 Oct-Nov;9(7):586-90; quiz 591.
Superantigens are strong modulators of the immune system affecting T cells, antigen-presenting cells and other MHC class II-positive cells directly and many other cells indirectly, e.g. mast cells that have bound IgE specific for superantigens. The strong immunomodulatory effects, which are outlined in this article besides the biological properties of superantigens, strongly influence immunologically-mediated disorders including inflammatory skin diseases like atopic dermatitis and psoriasis, which are the focus of this article.
超抗原是免疫系统的强效调节剂，可直接影响T细胞、抗原呈递细胞和其他II类主要组织相容性复合体（MHC）阳性细胞，并间接影响许多其他细胞，例如已结合针对超抗原的特异性IgE的肥大细胞。除超抗原的生物学特性外，本文概述的强效免疫调节作用强烈影响免疫介导的疾病，包括特应性皮炎和银屑病等炎症性皮肤病，这些疾病是本文的重点。
