Kieseier B C, Archelos J J, Storch M, Gold R, Hartung H P
Department of Neurology, Karl-Franzens-Universität, Graz, Austria.
Wien Klin Wochenschr. 1999 Sep 17;111(17):728-37.
The etiology of multiple sclerosis (MS) still remains elusive. However, the association of the disease with relevant genes, the characteristic white matter infiltrates, similarities with animal models, and the fact that MS can be treated with immunomodulatory and immunosuppressive therapies support the notion that this disorder is autoimmune in nature. During the last few years the knowledge about the mechanisms involved in the pathogenesis of MS increased rapidly. In this review, recent advances in our understanding about relevant pathomechanisms in inflammatory demyelinating diseases of the central nervous system will be discussed and the rational of some novel immunotherapies is explained in context of the current understanding of immunological principles.
多发性硬化症（MS）的病因仍然不明。然而，该疾病与相关基因的关联、特征性的白质浸润、与动物模型的相似性，以及MS可通过免疫调节和免疫抑制疗法进行治疗这一事实，均支持了这种疾病本质上是自身免疫性疾病的观点。在过去几年中，关于MS发病机制所涉及的机制的知识迅速增加。在这篇综述中，我们将讨论对中枢神经系统炎性脱髓鞘疾病相关发病机制的最新认识进展，并结合当前对免疫学原理的理解来解释一些新型免疫疗法的原理。
