一些异恶唑基萘醌衍生物的溶解度曲线

Solubility profiles of some isoxazolyl-naphthoquinone derivatives.

作者信息

Granero G, de Bertorello M M, Briñón M C

机构信息

Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, 5000, Córdoba, Argentina.

出版信息

Int J Pharm. 1999 Nov 10;190(1):41-7. doi: 10.1016/s0378-5173(99)00245-8.

DOI:10.1016/s0378-5173(99)00245-8

PMID:10528095

Abstract

Water, ethanol and n-hexane solubility and pH-solubility behavior of a homologous series of isoxazolyl-naphthoquinone derivatives, which exhibit important biological activity, were studied. Their pK(a) values were determined spectrophotometrically as well as from their pH-solubility profiles. Also, the molar aqueous solubility of these compounds was estimated with the equations developed by Yalkowsky and Valvani using the data of their melting points and octanol/water partition coefficients.

摘要

研究了一系列具有重要生物活性的异恶唑基萘醌衍生物的水、乙醇和正己烷溶解性以及pH-溶解性行为。通过分光光度法并根据其pH-溶解性曲线测定了它们的pK(a)值。此外，利用Yalkowsky和Valvani开发的方程，根据这些化合物的熔点和正辛醇/水分配系数数据估算了它们在水中的摩尔溶解度。