利用分配系数和熔点估算某些鸟嘌呤衍生物的水溶性
Estimation of aqueous solubility for some guanine derivatives using partition coefficient and melting temperature.
作者信息
Kristl A
机构信息
Faculty of Pharmacy, University of Ljubljana, Askerceva 7, 1000 Ljubljana, Slovenia.
出版信息
J Pharm Sci. 1999 Jan;88(1):109-10. doi: 10.1021/js980180z.
PMID:9874710
Abstract
Aqueous solubilities for some guanine derivatives were estimated by semiempirical equations developed by Yalkowsky and Valvani1 using the data for partition coefficient and melting temperature. It was shown that in the case of guanine derivatives examined in this study, the solubility values could not be estimated adequately by these equations.
摘要
利用分配系数和熔点数据，通过Yalkowsky和Valvani1开发的半经验方程估算了一些鸟嘌呤衍生物的水溶性。结果表明，在本研究中所检测的鸟嘌呤衍生物的情况下，这些方程无法充分估算其溶解度值。
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