Vol'kenshteĭn M V
Mol Biol (Mosk). 1976 May-Jun;10(2):498-500.
The investigation of 163 spontaneous point mutations of the human hemoglobin and the analysis of the genetic code make it possible to estimate the relative probability of transversions, which happens to be 0.30. From 23 possible nonsense mutations 15 are the transversions. Hence the genetic code provides the low probability of the mutational termination of the protein chain. The most dangerous are the mutations in the codon UGG (Trp).
对人类血红蛋白163个自发点突变的研究以及对遗传密码的分析,使得估计颠换的相对概率成为可能,其结果恰好为0.30。在23种可能的无义突变中,有15种是颠换。因此,遗传密码使得蛋白质链发生突变终止的概率较低。最危险的是密码子UGG(色氨酸)中的突变。