Szeszko P R, Robinson D, Alvir J M, Bilder R M, Lencz T, Ashtari M, Wu H, Bogerts B
Department of Psychiatry Research, Hillside Hospital, North-Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA.
Arch Gen Psychiatry. 1999 Oct;56(10):913-9. doi: 10.1001/archpsyc.56.10.913.
Functional neuroimaging studies have implicated the frontal lobes and the hippocampus-amygdala complex in the pathophysiology of obsessive-compulsive disorder (OCD). These brain regions have not been well investigated in patients with OCD, however, using magnetic resonance imaging.
Volumes of the superior frontal gyrus, anterior cingulate gyrus, orbital frontal region, hippocampus, and amygdala were computed from contiguous magnetic resonance images in a sample of 26 patients with OCD and 26 healthy comparison subjects.
Patients with OCD had significantly reduced bilateral orbital frontal and amygdala volumes compared with healthy comparison subjects and lacked the normal hemispheric asymmetry of the hippocampus-amygdala complex. Neither brain structure volumes nor asymmetry indices were significantly correlated with total illness duration or length of current OCD episode.
Findings of reduced orbital frontal and amygdala volumes in patients implicate a structural abnormality of these brain regions in the pathophysiology of OCD. Absence of the normal hemispheric asymmetry of the hippocampus-amygdala complex in patients is consistent with an anomalous neurodevelopmental process.
功能神经影像学研究表明，额叶及海马体 - 杏仁核复合体与强迫症（OCD）的病理生理学有关。然而，尚未使用磁共振成像对强迫症患者的这些脑区进行充分研究。
从26例强迫症患者和26例健康对照者的连续磁共振图像中计算出额上回、前扣带回、眶额区、海马体和杏仁核的体积。
与健康对照者相比，强迫症患者双侧眶额和杏仁核体积显著减小，且缺乏海马体 - 杏仁核复合体正常的半球不对称性。脑结构体积和不对称指数均与总病程或当前强迫症发作时长无显著相关性。
患者眶额和杏仁核体积减小的结果表明这些脑区的结构异常与强迫症的病理生理学有关。患者海马体 - 杏仁核复合体缺乏正常的半球不对称性与异常的神经发育过程一致。
