利用尸检脑组织研究强迫症：系统综述。
Use of Post-mortem Brain Tissue in Investigations of Obsessive- Compulsive Disorder: A Systematic Review.
机构信息
SA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, University of Stellenbosch, Stellenbosch, South Africa.
Department of Psychiatry and Mental Health & Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
出版信息
Curr Neuropharmacol. 2024;22(5):963-975. doi: 10.2174/1570159X21666230829145425.
BACKGROUND
Post-mortem examination of the brain is a key strategy to increase our understanding of the neurobiology of mental disorders. While extensive post-mortem research has been undertaken on some mental disorders, others appear to have been relatively neglected.
OBJECTIVE
The objective of the study was to conduct a systematic review of post-mortem research on obsessive-compulsive disorder (OCD).
METHODS
A systematic review was performed in accordance with PRISMA guidelines to provide an overview of quantitative, qualitative, or mixed methods primary research studies on OCD. Search platforms included NCBI Pubmed, SCOPUS, and Web of Science.
RESULTS
A total of 52 publications were found, and after the removal of works not meeting the inclusion criteria, six (6) peer-reviewed publications remained. These post-mortem studies have provided data on DNA methylation, cellular and molecular alterations, and gene expression profiling in brain areas associated with OCD.
DISCUSSION AND CONCLUSION
Included studies highlight the potential value of post-mortem brains from well-characterized individuals with OCD and suggest the need for additional work in this area.
背景
尸检是增加对精神障碍神经生物学理解的关键策略。虽然已经对一些精神障碍进行了广泛的尸检研究，但其他一些精神障碍似乎相对被忽视。
目的
本研究旨在对强迫症（OCD）的尸检研究进行系统综述。
方法
根据 PRISMA 指南进行系统综述，以提供关于 OCD 的定量、定性或混合方法的原始研究的概述。搜索平台包括 NCBI Pubmed、SCOPUS 和 Web of Science。
结果
共发现 52 篇出版物，在剔除不符合纳入标准的作品后，剩下 6 篇同行评议的出版物。这些尸检研究提供了与 OCD 相关脑区的 DNA 甲基化、细胞和分子改变以及基因表达谱的数据。
讨论与结论
纳入的研究强调了对具有良好特征的 OCD 个体的尸检大脑的潜在价值，并表明该领域需要进一步的研究。
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