[再生小鼠肝脏中mRNA的代谢：mRNA加工与降解的加速]
[Metabolism of mRNA in regenerating mouse liver: acceleration of the processing and decay of mRNA].
作者信息
Chernovskaia T V, Liubimova E V, Lerman M I
出版信息
Mol Biol (Mosk). 1976 Nov-Dec;10(6):1361-8.
The kinetics of accumulation of poly(A+)mRNA in polyribosomes and the ratio: poly(A+)mRNA/(poly A-)mRNA were studied in regenerating mouse liver. It has been found, that the ratio: (poly A+)mRNA/(poly A-)mRNA was associated with the function of the cells: (poly A+)mRNA fraction has been decreased to 7% at 7 hours after partial hepatectomy and then reached the original value (25%) at 30-40 hours. The kinetics of accumulation of (poly A+)mRNA in polyribosomes during the transition from resting to growing state has revealed that both the lifetime and the presumable time of processing of the mRNAs of free and membranebound polyribosomes were decreased as compared to resting liver cells.
在再生的小鼠肝脏中研究了多核糖体中聚腺苷酸（poly(A+)）mRNA的积累动力学以及聚腺苷酸（poly(A+)）mRNA与非聚腺苷酸（poly(A-)）mRNA的比例。已发现，该比例：（聚腺苷酸（poly(A+)）mRNA）/（非聚腺苷酸（poly(A-)）mRNA）与细胞功能相关：在部分肝切除术后7小时，聚腺苷酸（poly(A+)）mRNA部分降至7%，然后在30 - 40小时达到原始值（25%）。在从静止状态转变为生长状态期间，多核糖体中聚腺苷酸（poly(A+)）mRNA的积累动力学表明，与静止肝细胞相比，游离和膜结合多核糖体的mRNA的寿命以及可能的加工时间均缩短。
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