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[辅助循环。心脏同步外周动脉-动脉反搏对急性透壁性心肌缺血区域灌注和代谢的影响]

[Assisted circulation. The effect of cardio-synchronous peripheral arterio-arterial counterpulsation on perfusion and metabolism in the area of acute transmural myocardial ischemia].

作者信息

Otto H H, Buchali K, Krause E G

出版信息

Z Exp Chir. 1975;8(3):160-7.

PMID:1053176
Abstract

After establishing a model of ischemia, perfusion in the ischemic area was considerably disturbed. Examination by means of 133xenon-clearance after intramyocardiac injection showed strongly delayed flowing-off compared with controls. Counterpulsation accelerates the flowing-off (perfusion). Untreated control animals reveal after inducing the model ischemia a crucial decrease of ATP concentration and an excessive increase of lactate concentration in the ischemic area. Counterpulsation may inhibit further decrease of ATP in the ischemic area.

摘要

建立缺血模型后,缺血区域的灌注受到严重干扰。心肌内注射后通过133氙清除法检查发现,与对照组相比,血流流出明显延迟。反搏可加速血流流出(灌注)。未治疗的对照动物在诱导模型缺血后,缺血区域的ATP浓度显著降低,乳酸浓度过度升高。反搏可抑制缺血区域ATP的进一步降低。

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