Wolf R, Barz H
Z Exp Chir. 1975;8(4):215-21.
After long-term exhibition to halothane (up to 96 hours), centrolobular hepatic damage (fatty degeneration, necrobiosis and necrosis) developed in rats, proportionally to the number of anesthesias and shortening of the intervals. From these results no hepatotoxic effect of halothane can be derived, since the alterations might be caused by hypoxia alone.
大鼠经长期接触氟烷（长达96小时）后，出现小叶中心性肝损伤（脂肪变性、渐进性坏死和坏死），其程度与麻醉次数及间隔时间缩短成正比。从这些结果中无法得出氟烷具有肝毒性作用的结论，因为这些改变可能仅由缺氧引起。
