Guggenbichler J P, Kienel G
Padiatr Padol. 1979;14(1):69-74.
After the administration of a liquid suspension of Penicillin V-K, Epicillin, Cephalexin, Ampicillin, Pivampicillin and Amoxycillin on fasting and not fasting children, plasma levels and urine excretion of antibiotics were determined. A standard meal influences in Penicillin V-K and Ampicillin not only the maximum plasma levels, but also the absorbed amount of the drug. In Epicillin, Pivampicillin and Cephalexin we were not able to detect an influence of food on absorption. Amoxycillin doesn't seem to be impaired by food. However, the considerable individual differences could have its reasons in a number of other factors presently investigated.
在空腹和非空腹儿童中给予青霉素V-K、依匹西林、头孢氨苄、氨苄西林、匹氨西林和阿莫西林的液体混悬剂后，测定了抗生素的血浆水平和尿排泄量。一顿标准餐对青霉素V-K和氨苄西林的影响不仅在于血浆最高水平，还在于药物的吸收量。对于依匹西林、匹氨西林和头孢氨苄，我们未能检测到食物对吸收的影响。食物似乎不会影响阿莫西林的吸收。然而，个体差异较大可能是由目前正在研究的许多其他因素导致的。
