Wiechmann R J, Ferguson M K, Naunheim K S, Hazelrigg S R, Mack M J, Aronoff R J, Weyant R J, Santucci T, Macherey R, Landreneau R J
Allegheny University Hospitals, Allegheny General, Pittsburgh, PA 15212-4772, USA.
J Thorac Cardiovasc Surg. 1999 Nov;118(5):916-23. doi: 10.1016/s0022-5223(99)70062-0.
Video-assisted surgical approaches to esophageal achalasia continue to be explored by many surgeons involved in the management of this motor disorder. We report our experience with thoracoscopic and laparoscopic esophagomyotomy to more clearly define the efficacy and safety of these approaches.
Over 73 months, 58 patients with achalasia underwent thoracoscopic myotomy (n = 19) alone or laparoscopic myotomy (n = 39) with partial fundoplication (anterior = 15; posterior = 24). Mean age was 47.2 years and average length of symptoms was 60 months. Primary symptoms were as follows: dysphagia, 100%; pulmonary abnormalities, 22%; weight loss; 47%, and pain, 45%. Mean esophageal diameter was 6 cm and tortuosity was present in 16% (9/58) of patients. Prior management consisted of dilation (n = 47), botulinum toxin injection (n = 8), and prior myotomy (n = 1).
In the operating room all patients underwent endoscopic examination and evacuation of retained esophageal contents. The esophagomyotomy was extended 4 cm superiorly and inferiorly to 1 cm beyond the lower esophageal sphincter. Thoracoscopic and laparoscopic procedures were completed in all patients without conversion to an open operation. Mean operative time was 183 minutes (+/-58.1) and hospital stay averaged 2.3 days (+/-0.8). There was no operative mortality. The 1 operative complication was a perforation that was identified during the operation and repaired thoracoscopically.
Symptoms improved in 97% of patients. Mean dysphagia scores (range 0-10) decreased from 9.8 +/- 1.6 before the operation to 2.0 +/- 1.5 after the operation (P <.001) at a mean follow-up of 6 months. Postoperative reflux symptoms developed in 5% (1/19) of the thoracoscopy group and 8% (4/39) of the laparoscopy group. Nine patients have persistent or recurrent dysphagia (16%). Seven patients have successfully undergone Savary dilation, and 2 required esophagectomy to manage recalcitrant dysphagia.
At this intermediate term analysis, video-assisted approaches for management of achalasia are a reasonable alternative to extended medical therapy or open operations.
许多参与食管失弛缓症治疗的外科医生仍在探索视频辅助手术治疗该运动障碍的方法。我们报告我们进行胸腔镜和腹腔镜食管肌层切开术的经验,以更明确这些方法的疗效和安全性。
在73个月期间,58例失弛缓症患者接受了单纯胸腔镜肌层切开术(n = 19)或腹腔镜肌层切开术(n = 39)并加做部分胃底折叠术(前位 = 15例;后位 = 24例)。平均年龄为47.2岁,症状平均持续时间为60个月。主要症状如下:吞咽困难,100%;肺部异常,22%;体重减轻,47%;疼痛,45%。平均食管直径为6 cm,16%(9/58)的患者存在食管迂曲。既往治疗包括扩张术(n = 47)、肉毒杆菌毒素注射(n = 8)和既往肌层切开术(n = 1)。
在手术室,所有患者均接受内镜检查并清除食管内潴留物。食管肌层切开术在食管下括约肌上方4 cm和下方4 cm处进行,延伸至食管下括约肌下方1 cm处。所有患者均顺利完成胸腔镜和腹腔镜手术,未中转开放手术。平均手术时间为183分钟(±58.1),平均住院时间为2.3天(±0.8)。无手术死亡病例。1例手术并发症为术中发现的穿孔,经胸腔镜修复。
97%的患者症状改善。平均吞咽困难评分(范围0 - 10)从术前的9.8 ± 1.6降至术后6个月时的2.0 ± 1.5(P <.001)。胸腔镜组5%(1/19)和腹腔镜组8%(4/39)出现术后反流症状。9例患者存在持续性或复发性吞咽困难(16%)。7例患者成功接受了Savary扩张术,2例患者因顽固性吞咽困难需要行食管切除术。
在本次中期分析中,视频辅助手术治疗失弛缓症是延长药物治疗或开放手术的合理替代方案。