Luketich J D, Fernando H C, Christie N A, Buenaventura P O, Keenan R J, Ikramuddin S, Schauer P R
University of Pittsburgh Medical Center Health System, Pennsylvania, USA.
Ann Thorac Surg. 2001 Dec;72(6):1909-12; discussion 1912-3. doi: 10.1016/s0003-4975(01)03127-7.
Thoracic surgeons traditionally performed thoracotomy and myotomy for achalasia. Recently minimally invasive approaches have been reported with good success. This report summarizes our single-institution experience using video-assisted thoracoscopy (VATS) or laparoscopy (LAP) for the treatment of achalasia.
A review of 62 patients undergoing minimally invasive myotomy for achalasia was performed. There were 27 male and 35 female patients. Mean age was 53 years (range 14 to 86). Thirty-seven (59.7%) had failed prior treatments (balloon dilation, botulinim toxin injection, or prior surgery). Outcomes studied were dysphagia score (1 = none, 5 = severe), Short-Form 36 quality of life (SF36 QOL) score, and heartburn-related QOL index (HRQOL).
Surgery included myotomy and partial fundoplication (5 VATS and 57 LAP). Mortality was zero, and complications occurred in 9 (14.5%) patients. There were 6 perforations (4 repaired by LAP and 2 open). Median length of stay was 2 days, time to oral intake was 1 day. At a mean of 19 months follow-up, 92.5% of patients were satisfied with outcome. Dysphagia scores improved from 3.6 to 1.5 (p < 0.01) but 3 patients ultimately required esophagectomy for recurrent dysphagia. HRQOL scores for heartburn and SF-36 QOL scores were comparable with control populations.
Minimally invasive myotomy and partial fundoplication for achalasia improved dysphagia in 92.5% of patients with heartburn and QOL scores were comparable with normal values at 19-month follow-up. The laparoscopic approach offers excellent results and was the preferred approach by our thoracic group for treating achalasia. Thoracic residency training should strive to include laparoscopic esophageal experience.
传统上,胸外科医生采用开胸手术和肌切开术治疗贲门失弛缓症。最近有报道称,微创方法取得了良好的效果。本报告总结了我们单机构使用电视辅助胸腔镜(VATS)或腹腔镜(LAP)治疗贲门失弛缓症的经验。
对62例行贲门失弛缓症微创肌切开术的患者进行回顾性研究。其中男性27例,女性35例。平均年龄53岁(范围14至86岁)。37例(59.7%)患者先前治疗(球囊扩张、肉毒杆菌毒素注射或先前手术)失败。研究的结果指标包括吞咽困难评分(1 = 无,5 = 严重)、简明健康状况调查量表36项生活质量(SF36 QOL)评分以及烧心相关生活质量指数(HRQOL)。
手术包括肌切开术和部分胃底折叠术(5例VATS和57例LAP)。死亡率为零,9例(14.5%)患者出现并发症。有6例穿孔(4例通过LAP修复,2例开腹修复)。中位住院时间为2天,开始经口进食时间为1天。平均随访19个月时,92.5%的患者对治疗结果满意。吞咽困难评分从3.6改善至1.5(p < 0.01),但3例患者最终因复发性吞咽困难需要行食管切除术。烧心的HRQOL评分和SF - 36 QOL评分与对照组人群相当。
贲门失弛缓症的微创肌切开术和部分胃底折叠术使92.5%有烧心症状的患者吞咽困难得到改善,且在19个月随访时生活质量评分与正常值相当。腹腔镜手术效果极佳,是我们胸外科团队治疗贲门失弛缓症的首选方法。胸外科住院医师培训应努力纳入腹腔镜食管手术经验。