Ide F, Shimoyama T, Horie N, Kaneko T
Department of Oral Surgery, Saitama Medical Center, Saitama Medical School, Kawagoe, Japan.
J Oral Pathol Med. 1999 Oct;28(9):420-2. doi: 10.1111/j.1600-0714.1999.tb02114.x.
This report describes a case of primary intraosseous carcinoma (PIOC) arising de novo in the mandible. The patient was a 74-year-old woman and an early PIOC was found incidentally during histopathological examination of the pericoronal tissue obtained at extraction of a deeply impacted third molar. The curetted soft tissues consisted of a microinvasive, keratinizing squamous cell carcinoma with scattered foci of carcinoma cells showing calcification; stromal osseous metaplasia was also observed. After additional treatment, the patient has remained free of disease for 2 years. Since the tumor was completely enclosed in the bone, the only identifiable source of the present PIOC is the reduced enamel epithelium. Despite its rarity, this case emphasizes the importance of careful histologic examination of all apparently innocuous dental follicles that are removed surgically.
本报告描述了一例在下颌骨中初发的原发性骨内癌（PIOC）。患者为一名74岁女性，在拔除一颗深度阻生的第三磨牙时获取的冠周组织的组织病理学检查中偶然发现早期PIOC。刮除的软组织由微侵袭性角化鳞状细胞癌组成，癌细胞散在灶显示钙化；还观察到基质骨化生。经过进一步治疗，患者已无病生存2年。由于肿瘤完全包埋在骨内，目前PIOC唯一可识别的来源是缩余釉上皮。尽管该病罕见，但该病例强调了对所有手术切除的看似无害的牙囊进行仔细组织学检查的重要性。
