Newman F A, Strauss R D, Reznick S E, Bortolussi M E, Cummins M J, Stuckey J H
Surgery. 1975 Jan;77(1):154-9.
In ten dogs undergoing high cervical cardotomy, there was a statistically significant fall in plasma serotonin (5-HT) levels in portal vein blood; no further change in plasma 5-HT occurred after superior mesenteric artery (SMA) occlusion, which is an effective stimulus for 5-HT release. In five dogs undergoing high cervical corotomy with no SMA occlusion, there was a comparable fall in portal vein plasma 5-HT levels. The 5-hydroxyindoleacetic acid (5-HIAA) values in portal vein blood in the two groups of dogs above fell to comparable levels. These findings indicate (1) that maintenance of the normal plasma 5-HT level in portal vein blood in this experimental model is dependent on the integrity of the spinal cord and (2) that SMA occlusion in animals with a high cervical cordotomy does not result in further changes in the plasma 5-HT level in portal vein blood.
在10只接受高位颈髓切断术的犬中，门静脉血中血浆5-羟色胺（5-HT）水平出现了具有统计学意义的下降；在肠系膜上动脉（SMA）闭塞后，血浆5-HT没有进一步变化，而SMA闭塞是5-HT释放的有效刺激因素。在5只接受高位颈髓切断术且未进行SMA闭塞的犬中，门静脉血浆5-HT水平出现了类似的下降。上述两组犬门静脉血中的5-羟吲哚乙酸（5-HIAA）值降至相当水平。这些发现表明：（1）在该实验模型中，门静脉血中正常血浆5-HT水平的维持依赖于脊髓的完整性；（2）在进行高位颈髓切断术的动物中，SMA闭塞不会导致门静脉血中血浆5-HT水平的进一步变化。
