慢性髓性白血病急变后发生的脑膜白血病。

Meningeal leukemia after blastic transformation of chronic myeloid leukemia.

作者信息

Atkinson K, Kay H E, Lawler S D, Wells D G, McElwain T J

出版信息

Cancer. 1975 Feb;35(2):529-33. doi: 10.1002/1097-0142(197502)35:2<529::aid-cncr2820350235>3.0.co;2-u.

DOI:10.1002/1097-0142(197502)35:2<529::aid-cncr2820350235>3.0.co;2-u

Abstract

In two patients with blastic transformation of chronic myeloid leukemia complete remission was induced, but meningeal leukemia subsequently developed. The recognition of blast cell crisis as the presenting feature of chronic myeloid leukemia is discussed, together with treatment of this condition and its rare complication, meningeal leukemia. The development of meningeal leukemia in this disease is almost certainly due to the increased survival that has been produced by advances in therapy for blastic transformation.

摘要

在两名慢性髓性白血病急变期患者中诱导出了完全缓解，但随后发生了脑膜白血病。本文讨论了将原始细胞危象识别为慢性髓性白血病的首发特征，以及对这种情况及其罕见并发症脑膜白血病的治疗。在这种疾病中脑膜白血病的发生几乎肯定是由于针对急变期治疗进展所带来的生存期延长。