Mandelli F, Amadori S, Alimena G, Annino L, Nardelli S, Papa G
Scand J Haematol. 1977 Nov;19(5):496-502. doi: 10.1111/j.1600-0609.1977.tb01506.x.
A group of 50 patients with chronic myelocytic leukaemia in blastic crisis were treated with different chemotherapeutic regimens. A total of 19 remissions (6 CR + 13 PR) were achieved with an overall and complete response rate of 38% and 12% respectively. Of the 4 patients presenting with a lymphoblast-like appearance of the blasts, the 3 treated with the combination of vincristine and prednisone all achieved remission (2 CR + 1 PR). Duration of survival was significantly longer in responding patients (median 11.5 versus 4.5 months). Either more effective therapeutic regimens or prevention by aggressively approaching the chronic phase are to be sought in order to improve the prognosis of blastic crisis of CML.
一组50例处于急变期的慢性粒细胞白血病患者接受了不同的化疗方案治疗。共获得19例缓解（6例完全缓解+13例部分缓解），总缓解率和完全缓解率分别为38%和12%。在4例原始细胞呈淋巴母细胞样外观的患者中，接受长春新碱和泼尼松联合治疗的3例均获得缓解（2例完全缓解+1例部分缓解）。缓解患者的生存期明显更长（中位生存期11.5个月对4.5个月）。为了改善慢性粒细胞白血病急变期的预后，需要寻求更有效的治疗方案或通过积极控制慢性期来进行预防。
