日本脆弱拟杆菌菌株中cfiA基因的分布及cfiA与亚胺培南耐药性的相关性
Distribution of the cfiA gene among Bacteroides fragilis strains in Japan and relatedness of cfiA to imipenem resistance.
作者信息
Yamazoe K, Kato N, Kato H, Tanaka K, Katagiri Y, Watanabe K
机构信息
Institute of Anaerobic Bacteriology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu 500-8705, Japan.
出版信息
Antimicrob Agents Chemother. 1999 Nov;43(11):2808-10. doi: 10.1128/AAC.43.11.2808.
Abstract
The cfiA gene, encoding an imipenem-hydrolyzing metallo-beta-lactamase produced by Bacteroides fragilis, and insertion-like elements were detected by PCR amplification with B. fragilis strains isolated in Japan. The cfiA gene was found in 1.9 and 4.1% of the imipenem-susceptible B. fragilis isolates collected from 1987 to 1988 and from 1992 to 1994, respectively. Insertion-like elements adjacent to the cfiA gene were found in all nine metallo-beta-lactamase-producing imipenem-resistant strains tested but not in nine cfiA-positive strains with no detectable metallo-beta-lactamase activity.
摘要
采用从日本分离的脆弱拟杆菌菌株，通过聚合酶链反应（PCR）扩增检测到了cfiA基因，该基因编码由脆弱拟杆菌产生的一种水解亚胺培南的金属β-内酰胺酶以及插入样元件。在分别于1987年至1988年以及1992年至1994年收集的对亚胺培南敏感的脆弱拟杆菌分离株中，cfiA基因的检出率分别为1.9%和4.1%。在所检测的全部9株产金属β-内酰胺酶的亚胺培南耐药菌株中均发现了与cfiA基因相邻的插入样元件，但在9株未检测到金属β-内酰胺酶活性的cfiA阳性菌株中未发现。
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