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Detection of carbapenemase activities of Bacteroides fragilis strains with matrix-assisted laser desorption ionization--time of flight mass spectrometry (MALDI-TOF MS).应用基质辅助激光解吸电离飞行时间质谱（MALDI-TOF MS）检测脆弱拟杆菌菌株的碳青霉烯酶活性。
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本文引用的文献

1
Matrix-assisted laser desorption ionization time-of-flight mass spectrometry, a revolution in clinical microbial identification.基质辅助激光解吸电离飞行时间质谱技术，临床微生物鉴定的一场革命。
Clin Microbiol Infect. 2010 Nov;16(11):1614-9. doi: 10.1111/j.1469-0691.2010.03311.x.
2
Performance of a matrix-assisted laser desorption ionization-time-of-flight mass spectrometry system for the identification of bacterial isolates in the clinical routine laboratory.基质辅助激光解吸电离飞行时间质谱系统在临床常规实验室中用于鉴定细菌分离株的性能
Clin Lab. 2009;55(7-8):289-96.
3
Ongoing revolution in bacteriology: routine identification of bacteria by matrix-assisted laser desorption ionization time-of-flight mass spectrometry.细菌学领域正在进行的变革：通过基质辅助激光解吸电离飞行时间质谱法对细菌进行常规鉴定。
Clin Infect Dis. 2009 Aug 15;49(4):543-51. doi: 10.1086/600885.
4
Species identification of clinical isolates of Bacteroides by matrix-assisted laser-desorption/ionization time-of-flight mass spectrometry.采用基质辅助激光解吸/电离飞行时间质谱法对拟杆菌临床分离株进行菌种鉴定。
Clin Microbiol Infect. 2009 Aug;15(8):796-802. doi: 10.1111/j.1469-0691.2009.02788.x. Epub 2009 May 11.
5
Evaluation of a new meropenem-EDTA double-ended Etest strip for the detection of the cfiA metallo-beta-lactamase gene in clinical isolates of Bacteroides fragilis.评价一种新型美罗培南-乙二胺四乙酸双端Etest试纸条用于检测脆弱拟杆菌临床分离株中cfiA金属β-内酰胺酶基因。
Clin Microbiol Infect. 2008 Oct;14(10):973-7. doi: 10.1111/j.1469-0691.2008.02065.x.
6
Examination of cfiA-mediated carbapenem resistance in Bacteroides fragilis strains from a European antibiotic susceptibility survey.在一项欧洲抗生素敏感性调查中对脆弱拟杆菌菌株中cfiA介导的碳青霉烯类耐药性进行检测。
Int J Antimicrob Agents. 2006 Dec;28(6):497-502. doi: 10.1016/j.ijantimicag.2006.07.021. Epub 2006 Nov 13.
7
Third Belgian multicentre survey of antibiotic susceptibility of anaerobic bacteria.比利时第三次厌氧菌抗生素敏感性多中心调查。
J Antimicrob Chemother. 2007 Jan;59(1):132-9. doi: 10.1093/jac/dkl458. Epub 2006 Nov 9.
8
Molecular characterization of imipenem-resistant, cfiA-positive Bacteroides fragilis isolates from the USA, Hungary and Kuwait.来自美国、匈牙利和科威特的耐亚胺培南、cfiA阳性脆弱拟杆菌分离株的分子特征分析。
J Med Microbiol. 2004 May;53(Pt 5):413-419. doi: 10.1099/jmm.0.05452-0.
9
RecA and glnA sequences separate the bacteroides fragilis population into two genetic divisions associated with the antibiotic resistance genotypes cepA and cfiA.RecA和谷氨酰胺合成酶基因序列将脆弱拟杆菌群体分为两个与抗生素抗性基因型cepA和cfiA相关的遗传分支。
J Med Microbiol. 2002 Feb;51(2):123-130. doi: 10.1099/0022-1317-51-2-123.
10
Expression of the carbapenemase gene (cfiA) in Bacteroides fragilis.脆弱拟杆菌中碳青霉烯酶基因（cfiA）的表达
J Antimicrob Chemother. 2000 Dec;46(6):1009-12. doi: 10.1093/jac/46.6.1009.

基质辅助激光解吸电离飞行时间质谱法区分 cfiA 阴性和 cfiA 阳性脆弱拟杆菌分离株。

Differentiation of cfiA-negative and cfiA-positive Bacteroides fragilis isolates by matrix-assisted laser desorption ionization-time of flight mass spectrometry.

机构信息

Department of Microbiology and Infection Control, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium.

出版信息

J Clin Microbiol. 2011 May;49(5):1961-4. doi: 10.1128/JCM.02321-10. Epub 2011 Feb 23.

DOI:10.1128/JCM.02321-10
PMID:21346046
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3122694/
Abstract

Carbapenem resistance in Bacteroides fragilis is associated with cfiA-encoded class B metallo-beta-lactamase. cfiA-negative and cfiA-positive isolates belong to genotypically distinct groups. Of a total of 248 B. fragilis isolates included in this study, 214 were susceptible, 10 were intermediate, and 24 were resistant to meropenem. We show that matrix-assisted laser desorption ionization-time of flight mass spectrometry is able to differentiate between cfiA-negative and cfiA-positive isolates and predict carbapenem resistance in a routine laboratory setting.

摘要

脆弱拟杆菌的碳青霉烯耐药性与 cfiA 编码的 B 型金属β-内酰胺酶有关。cfiA 阴性和 cfiA 阳性分离株属于不同的基因型群体。在本研究中总共包括 248 株脆弱拟杆菌分离株，214 株为敏感株，10 株为中介株，24 株为美罗培南耐药株。我们表明基质辅助激光解吸电离飞行时间质谱能够区分 cfiA 阴性和 cfiA 阳性分离株，并在常规实验室环境中预测碳青霉烯类耐药性。