Jorkjend L, Skoglund L A
Section of Dental Pharmacology and Pharmacotherapy, University of Oslo, Norway.
Methods Find Exp Clin Pharmacol. 1999 Sep;21(7):505-10.
It is known that some local anesthetics may cause pain when the initial local anesthetic effect disappears. The aim of this trial was to compare the postoperative pain intensities after infiltration of plain lidocaine 1% and 2% used in gingivectomies. The trial was done as a controlled, randomized, double-blind, parallel group study involving 117 patients with mean age 48 years (range 29-71 years) allocated to two treatment groups. There was no statistically significant difference between the mean postoperative pain courses of lidocaine 1% and 2% after gingivectomies during an 11-h observation period. A numerical difference was seen from 7 to 11 h in favor of lidocaine 1%. There were more patients experiencing no pain, but more patients reporting higher pain scores in the lidocaine 2% group than in the lidocaine 1% group. These differences were not statistically significant. It can be concluded that there is apparently no difference between lidocaine 1% and 2% with respect to postoperative pain experience when using gingivectomy as a pain model.
众所周知,当最初的局部麻醉效果消失时,一些局部麻醉剂可能会引起疼痛。本试验的目的是比较在牙龈切除术时使用的1%和2%的普通利多卡因浸润后的术后疼痛强度。该试验作为一项对照、随机、双盲、平行组研究进行,涉及117例平均年龄48岁(范围29 - 71岁)的患者,分为两个治疗组。在11小时的观察期内,牙龈切除术后1%和2%利多卡因的平均术后疼痛过程之间没有统计学上的显著差异。在7至11小时之间观察到有利于1%利多卡因的数值差异。与1%利多卡因组相比,2%利多卡因组中无疼痛的患者更多,但报告更高疼痛评分的患者也更多。这些差异无统计学意义。可以得出结论,以牙龈切除术作为疼痛模型时,1%和2%利多卡因在术后疼痛体验方面显然没有差异。