一种在基因重组中激活同源DNA分子间分支迁移的机制。
A mechanism to activate branch migration between homologous DNA molecules in genetic recombination.
作者信息
Sobell H M
出版信息
Proc Natl Acad Sci U S A. 1975 Jan;72(1):279-83. doi: 10.1073/pnas.72.1.279.
Abstract
A mechanism to activate branch migration between homologous DNA molecules is described that leads to synapsis in genetic recombination. The model involves a restriction-like endonucleolytic enzyme that first nicks DNA (to produce single-strand breaks) on strands of opposite polarity at symmetrically arranged nucleotide sequences (located at ends of genes or operons). This is followed by local denaturation of the region, promoted by a single-strand-specific DNA binding protein (i.e., an unwinding protein). Hydrogen-bounding between homologous DNA molecules can then be initiated and this allows for subsequent propagation of hybrid DNA in the pathway to formation of the synapton structure.
摘要
描述了一种激活同源DNA分子间分支迁移的机制，该机制导致基因重组中的联会。该模型涉及一种类似限制酶的核酸内切酶，它首先在对称排列的核苷酸序列（位于基因或操纵子末端）处，在相反极性的链上切割DNA（产生单链断裂）。随后，由单链特异性DNA结合蛋白（即解旋蛋白）促进该区域的局部变性。然后可以启动同源DNA分子之间的氢键结合，这允许杂种DNA在形成联会结构的途径中随后传播。
相似文献
1
A mechanism to activate branch migration between homologous DNA molecules in genetic recombination.一种在基因重组中激活同源DNA分子间分支迁移的机制。
Proc Natl Acad Sci U S A. 1975 Jan;72(1):279-83. doi: 10.1073/pnas.72.1.279.
2
Molecular mechanism for genetic recombination.基因重组的分子机制。
Proc Natl Acad Sci U S A. 1972 Sep;69(9):2483-7. doi: 10.1073/pnas.69.9.2483.
3
Paranemic structures of DNA and their role in DNA unwinding.DNA的平行螺旋结构及其在DNA解旋中的作用。
Crit Rev Biochem Mol Biol. 1991;26(5-6):475-559. doi: 10.3109/10409239109086791.
4
Genetic recombination: recA protein promotes homologous pairing between duplex DNA molecules without strand unwinding.基因重组：RecA蛋白促进双链DNA分子间的同源配对，而无需解链。
Nucleic Acids Res. 1981 Aug 25;9(16):4201-10. doi: 10.1093/nar/9.16.4201.
5
Holliday junction cleavage by yeast Rad1 protein.酵母Rad1蛋白对霍利迪连接体的切割
Nature. 1994 Oct 6;371(6497):531-4. doi: 10.1038/371531a0.
6
Stable three-stranded DNA made by RecA protein.由RecA蛋白形成的稳定三链DNA。
Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):2984-8. doi: 10.1073/pnas.88.8.2984.
7
A general model for genetic recombination.遗传重组的通用模型。
Proc Natl Acad Sci U S A. 1975 Jan;72(1):358-61. doi: 10.1073/pnas.72.1.358.
8
[How does DNA recognize homologous sites and exchange strands? Molecular structure of DNA in homology search and strand exchange].[DNA如何识别同源位点并交换链？同源性搜索和链交换中DNA的分子结构]
Tanpakushitsu Kakusan Koso. 1999 Apr;44(5):631-42.
9
Synapsis promoted by Ustilago rec1 protein.黑粉菌rec1蛋白促进联会。
Cell. 1984 Mar;36(3):593-8. doi: 10.1016/0092-8674(84)90338-6.
10
Human meiotic recombinase Dmc1 promotes ATP-dependent homologous DNA strand exchange.人类减数分裂重组酶Dmc1促进ATP依赖的同源DNA链交换。
Nature. 2004 May 27;429(6990):433-7. doi: 10.1038/nature02563.
引用本文的文献
1
The allotetraploidization of maize : Part 1: The physical basis - differential pairing affinity.玉米的异源四倍体化：第 1 部分：物理基础-差异配对亲和力。
Theor Appl Genet. 1979 May;54(3):103-12. doi: 10.1007/BF01159463.
2
Double Holliday structure: a possible in vivo intermediate form of general recombination in Escherichia coli.双Holliday结构：大肠杆菌中一般重组可能的体内中间形式。
Mol Gen Genet. 1983;191(2):213-20. doi: 10.1007/BF00334816.
3
Apparent gene conversion between beta-tubulin genes yields multiple regulatory pathways for a single beta-tubulin polypeptide isotype.β-微管蛋白基因之间明显的基因转换为单一的β-微管蛋白多肽同种型产生了多种调控途径。
Mol Cell Biol. 1985 Sep;5(9):2454-65. doi: 10.1128/mcb.5.9.2454-2465.1985.
4
Antimutator activity during mitosis by a meiotic mutant of yeast.酵母减数分裂突变体在有丝分裂期间的抗突变活性。
Mol Gen Genet. 1975 Aug 5;139(1):9-18. doi: 10.1007/BF00267991.
5
Biochemical assay designed to detect formation of recombination intermediates in vitro.
Proc Natl Acad Sci U S A. 1979 Mar;76(3):1084-8. doi: 10.1073/pnas.76.3.1084.
6
Involvement of DNA-dependent RNA polymerase in a recA-independent pathway of genetic recombination in Escheria coli.DNA依赖性RNA聚合酶参与大肠杆菌中不依赖recA的基因重组途径。
Proc Natl Acad Sci U S A. 1977 Sep;74(9):3932-6. doi: 10.1073/pnas.74.9.3932.
本文引用的文献
1
Recombination in yeast.酵母中的重组
Annu Rev Genet. 1971;5:219-36. doi: 10.1146/annurev.ge.05.120171.001251.
2
Reciprocal recombination in prophage lambda.原噬菌体λ中的交互重组
J Cell Physiol. 1967 Oct;70(2):Suppl:113-8. doi: 10.1002/jcp.1040700409.
3
T4 bacteriophage gene 32: a structural protein in the replication and recombination of DNA.T4噬菌体基因32：DNA复制与重组中的一种结构蛋白。
Nature. 1970 Sep 26;227(5265):1313-8. doi: 10.1038/2271313a0.
4
Reciprocal recombination of chromosome and F. merogenote in Escherichia coli.大肠杆菌中染色体与部分二倍体的相互重组。
J Bacteriol. 1965 Dec;90(6):1664-8. doi: 10.1128/jb.90.6.1664-1668.1965.
5
Meiotic protein in spermatocytes of mammals.
Nat New Biol. 1971 Nov 17;234(46):83-6. doi: 10.1038/newbio234083a0.
6
Genotypes produced by individual recombination events involving bacteriophage f1.由涉及噬菌体f1的个体重组事件产生的基因型。
J Mol Biol. 1971 May 28;58(1):133-51. doi: 10.1016/0022-2836(71)90237-3.
7
Branched DNA molecules: intermediates in T4 recombination.分支DNA分子：T4重组中的中间体。
J Mol Biol. 1971 Aug 28;60(1):131-49. doi: 10.1016/0022-2836(71)90453-0.
8
Sequence of a repressor-binding site in the DNA of bacteriophage lamda.噬菌体λDNA中阻遏物结合位点的序列。
Nature. 1974 Aug 2;250(465):394-7. doi: 10.1038/250394a0.
9
Molecular mechanisms in genetic recombination.基因重组中的分子机制。
Annu Rev Genet. 1973;7:87-111. doi: 10.1146/annurev.ge.07.120173.000511.
10
The nucleotide sequence of the lac operator.乳糖操纵基因的核苷酸序列。
Proc Natl Acad Sci U S A. 1973 Dec;70(12):3581-4. doi: 10.1073/pnas.70.12.3581.
Zotero 插件