原代外植体造血细胞中的巯基依赖性。维生素B12化合物对体外生长的抑制作用。
Sulfhydryl dependence in primary explant hematopoietic cells. Inhibition of growth in vitro with vitamin B12 compounds.
作者信息
Toohey J I
出版信息
Proc Natl Acad Sci U S A. 1975 Jan;72(1):73-7. doi: 10.1073/pnas.72.1.73.
Abstract
Primary explants of P388, EL-4, and L1210 murine leukemia cells and of normal mouse bone marrow are shown to require sulfhydryl compounds for proliferation in vitro. Nine extablished cell lines show no stimulation by these compounds. Leukemia cells can lose the sulfhydryl dependence after various periods of adaptation to in vitro culture. Various sulfhydryl compounds have widely differing potencies in promoting in vitro proliferation of dependent cells. The effect appears to be specific for sulfhydryl groups in the reduced form. Vitamin B12 compounds inhibit the growth of sulfhydryl-requiring cells, apparently by catalyzing the oxidation of the sulfhydryl groups.
摘要
P388、EL-4和L1210小鼠白血病细胞以及正常小鼠骨髓的原代外植体在体外增殖需要巯基化合物。9种已建立的细胞系对这些化合物无刺激反应。白血病细胞在适应体外培养不同时间后可失去对巯基的依赖性。各种巯基化合物在促进依赖性细胞体外增殖方面的效力差异很大。这种作用似乎对还原形式的巯基具有特异性。维生素B12化合物抑制需要巯基的细胞生长，显然是通过催化巯基的氧化来实现的。
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