抗坏血酸：小鼠浆细胞瘤细胞形成集落的一种培养条件需求。
Ascorbic acid: a culture requirement for colony formation by mouse plasmacytoma cells.
作者信息
Park C H, Bergsagel D E, McCulloch E A
出版信息
Science. 1971 Nov 12;174(4010):720-2. doi: 10.1126/science.174.4010.720.
PMID:5123422
Abstract
Plasmacytoma stem cells explanted from mice formed colonies in culture only in the presence of L-ascorbic acid; this vitamin was not needed for the formation of granulocytic colonies. Isomers of L-ascorbic acid with less antiscorbutic activity also promoted plasmacytoma colony formation, but less effectively. Other redox compounds without antiscorbutic activity and an antioxidant were ineffective.
摘要
从小鼠体内分离出的浆细胞瘤干细胞仅在L-抗坏血酸存在的情况下才能在培养中形成集落；粒细胞集落的形成不需要这种维生素。抗坏血病活性较低的L-抗坏血酸异构体也能促进浆细胞瘤集落的形成，但效果较差。其他无抗坏血病活性的氧化还原化合物和一种抗氧化剂则无效。
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