Flaks B, Basley W A
Virchows Arch B Cell Pathol. 1979 Feb 6;29(4):309-20. doi: 10.1007/BF02899362.
Male rats were given a single intragastric dose of 2-acetylaminofluorene, 600 mg/kg body weight, killed at intervals up to 14 days after treatment, and their hepatic tissue examined by electron microscopy. The early cytoplasmic lesion produced in hepatocytes by lower doses, consisting of perinuclear glycogen pooling, peripheral displacement of organelles and pyknosis, was delayed for several days. Among the changes which appeared to be independent of this lesion were disorganization and decrease of the granular endoplasmic reticulum and abnormalities of the bile canaliculi. These changes were similar to those which are seen during chronic exposure to 2-AAF and other hepatocarcinogens and in hepatic cell tumours.
给雄性大鼠一次性灌胃给予2-乙酰氨基芴，剂量为600毫克/千克体重，在处理后长达14天的不同时间点处死大鼠，并通过电子显微镜检查其肝脏组织。较低剂量在肝细胞中产生的早期细胞质损伤，包括核周糖原聚集、细胞器外周移位和核固缩，会延迟数天出现。在似乎与这种损伤无关的变化中，有颗粒内质网的紊乱和减少以及胆小管的异常。这些变化与长期接触2-乙酰氨基芴和其他肝癌致癌物以及肝细胞肿瘤中所见的变化相似。
