Chow D R, Williams G A, Trese M T, Margherio R R, Ruby A J, Ferrone P J
McGill University, Montreal, Quebec, Canada.
Retina. 1999;19(5):405-9. doi: 10.1097/00006982-199909000-00006.
To establish the efficacy of vitreoretinal surgery without the use of transforming growth factor-beta or autologous platelet concentrate in the repair of traumatic macular holes.
This retrospective review consisted of 16 eyes from 16 consecutive patients treated by five vitreoretinal surgeons at a single institution between 1993 and 1997. Intervention included pars plana vitrectomy with creation of posterior vitreous detachment, placement of 14% to 16% C3F8 gas, and postoperative face-down positioning. Ten eyes received intraoperative autologous plasmin to facilitate formation of posterior vitreous detachment. Main outcome measures were anatomic closure rate and visual outcome.
Anatomic closure of the macular holes was achieved in 15 (94%) of 16 eyes, with an average follow-up of 7 months. Six (38%) eyes achieved visual acuity of 20/40 or better. Visual acuity improved by 2 or more lines in 11 (69%) of 16 eyes. The average preoperative logMAR-converted visual acuity of 20/175 improved to 20/60 postoperatively.
Traumatic macular holes can be closed successfully with substantial visual recovery without the use of transforming growth factor-beta or platelet concentrate.
确定在不使用转化生长因子-β或自体血小板浓缩物的情况下,玻璃体视网膜手术修复外伤性黄斑裂孔的疗效。
这项回顾性研究纳入了1993年至1997年间在单一机构由五位玻璃体视网膜外科医生连续治疗的16例患者的16只眼。干预措施包括经平坦部玻璃体切除术以形成玻璃体后脱离、注入14%至16%的C3F8气体以及术后面部朝下体位。10只眼术中接受自体纤溶酶以促进玻璃体后脱离的形成。主要观察指标为解剖学闭合率和视力结果。
16只眼中有15只(94%)黄斑裂孔实现了解剖学闭合,平均随访7个月。6只(38%)眼的视力达到20/40或更好。16只眼中有11只(69%)眼的视力提高了2行或更多。术前平均logMAR转换视力为20/175,术后提高到20/60。
在不使用转化生长因子-β或血小板浓缩物的情况下,外伤性黄斑裂孔能够成功闭合,视力有显著恢复。