Robinson J W, Saliken J C, Donnelly B J, Barnes P, Guyn L
Department of Oncology and Program in Clinical Psychology, University of Calgary, and Department of Psychosocial Resources, Tom Baker Cancer Centre, Calgary, Alberta, Canada.
Cancer. 1999 Nov 1;86(9):1793-801.
Cryosurgery was introduced as an alternative to radiotherapy or radical prostatectomy in the mid-1960s. Although it met the primary objective of achieving local control, it was largely abandoned due to a high incidence of complications. Technologic advances in the areas of imaging and urethral warming have renewed interest in this treatment methodology. The aim of the current study was to determine the quality of life of men enrolled in a Phase II clinical trial of cryosurgery for the treatment of localized prostate carcinoma.
Men were administered the Functional Assessment of Cancer Treatment-Prostate (FACT-P) prior to their treatment and at 6 weeks and 3, 6, and 12 months posttreatment.
By 12 months after cryosurgery, most of the FACT-P subscales had returned to pretreatment levels, following a decline in well-being immediately after cryosurgery. There were two exceptions to this general trend: At 12 months, impairments in social/family well-being and sexual function still remained. The average time to return to work after therapy was 3 weeks. Stay in hospital after treatment was limited to 1 day for 94% of the participants. Compared with men who received the standard treatments of radical prostatectomy and radical radiotherapy, men treated with cryosurgery appeared to have a similar quality of life, with perhaps the exception of decreased sexual function.
The quality-of-life outcomes of this study support the current renewed interest in cryosurgery. The severe impairments reported in other studies were not seen in this sample. In fact, it appeared that all aspects of the participants' well-being had returned to pretreatment levels by 12 months, with the exception of sexual function.
冷冻手术于20世纪60年代中期被引入，作为放射治疗或根治性前列腺切除术的替代方法。尽管它达到了实现局部控制的主要目标，但由于并发症发生率高，在很大程度上被弃用。成像和尿道加温领域的技术进步重新激发了人们对这种治疗方法的兴趣。本研究的目的是确定参加冷冻手术治疗局限性前列腺癌的II期临床试验的男性的生活质量。
在治疗前以及治疗后6周、3个月、6个月和12个月，对男性进行癌症治疗功能评估-前列腺（FACT-P）测试。
冷冻手术后12个月时，在冷冻手术后幸福感立即下降之后，FACT-P的大多数子量表已恢复到治疗前水平。这一总体趋势有两个例外：在12个月时，社会/家庭幸福感和性功能的损害仍然存在。治疗后平均重返工作岗位的时间为3周。94%的参与者治疗后住院时间限制在1天。与接受根治性前列腺切除术和根治性放射治疗等标准治疗的男性相比，接受冷冻手术治疗的男性生活质量似乎相似，性功能下降可能是个例外。
本研究的生活质量结果支持当前对冷冻手术重新产生的兴趣。本样本中未出现其他研究报告的严重损害情况。事实上，到12个月时，参与者幸福感的所有方面似乎都已恢复到治疗前水平，性功能除外。
