Mazario J, Herrero J F
Departamento de Fisiología, Facultad de Medicina, Universidad de Alcalá, Madrid, Spain.
Neurosci Lett. 1999 Oct 29;274(3):179-82. doi: 10.1016/s0304-3940(99)00721-1.
Metamizol has been considered as a peripherally acting non-steroidal antiinflammatory drug, though a central action is possible. The aim of the present study was to elucidate if metamizol induces antinociception in the single motor unit preparation, in normal rats versus rats with carrageenan-induced monoarthritis, and whether this action is produced at central and/or peripheral sites. Metamizol induced a potent antinociceptive effect in both groups of animals, though the effect on responses evoked by natural stimulation was stronger in hyperalgesic rats. Metamizol also depressed wind-up in a dose-dependent manner. We conclude that metamizol is a potent antinociceptive agent both in normal and hyperalgesic animals and that the effect was induced both at peripheral and central sites, at the level of the spinal cord.
安乃近一直被视为一种外周作用的非甾体抗炎药，不过也可能存在中枢作用。本研究的目的是阐明安乃近在单运动单位制备中是否能诱导正常大鼠和角叉菜胶诱导的单关节炎大鼠产生抗伤害感受，以及这种作用是在中枢和/或外周部位产生的。安乃近在两组动物中均诱导出强效的抗伤害感受作用，不过对超敏大鼠自然刺激诱发反应的作用更强。安乃近还以剂量依赖性方式抑制了累积放电。我们得出结论，安乃近在正常和超敏动物中都是一种强效的抗伤害感受剂，且这种作用是在脊髓水平的外周和中枢部位诱导产生的。
