人免疫球蛋白G抗体对链球菌致热外毒素A和B的相对亲和力。
Relative avidities of human immunoglobulin G antibodies for streptococcal pyrogenic exotoxins A and B.
作者信息
Mascini E M, Jansze M, Verhoef J, van Dijk H
机构信息
Eijkman-Winkler Institute for Microbiology, Infectious Diseases, and Inflammation, University Medical Center, Utrecht, The Netherlands.
出版信息
Clin Diagn Lab Immunol. 1999 Nov;6(6):977-80. doi: 10.1128/CDLI.6.6.977-980.1999.
Abstract
In this pilot study, we investigated the relative avidities for streptococcal pyrogenic exotoxin A (SPE-A) and SPE-B of antibodies in sera from patients with fatal streptococcal toxic shock-like syndrome and from healthy individuals and in intravenous immunoglobulin (IVIG) preparations. We observed a great variation in the relative avidities of patient, control, and IVIG immunoglobulin G (IgG) (values estimated to be between 10(-7) and 10(-11) M), with mean values for patient IgG about 10-fold lower than those of control IgG.
摘要
在这项初步研究中，我们调查了致命性链球菌中毒性休克样综合征患者及健康个体血清中的抗体以及静脉注射免疫球蛋白（IVIG）制剂对链球菌致热外毒素A（SPE-A）和SPE-B的相对亲和力。我们观察到患者、对照及IVIG免疫球蛋白G（IgG）的相对亲和力存在很大差异（估计值在10^(-7)至10^(-11) M之间），患者IgG的平均值比对照IgG低约10倍。
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本文引用的文献
1
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Clin Infect Dis. 1998 Mar;26(3):631-8. doi: 10.1086/514588.
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Invasive group A streptococcal disease. Association with a lack of anti-exotoxin antibodies.侵袭性A组链球菌病。与抗外毒素抗体缺乏相关。
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A new procedure for the purification of streptococcal pyrogenic exotoxin A from Streptococcus pyogenes supernatant.一种从化脓性链球菌上清液中纯化化脓性链球菌热原性外毒素A的新方法。
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