Gottesman M
College of Physicians and Surgeons of Columbia University, 701 West 168th Street, New York NY, 10032, USA.
J Mol Biol. 1999 Oct 22;293(2):177-80. doi: 10.1006/jmbi.1999.3137.
The study of bacteriophage lambda has provided key insights into fundamental biological processes. This review recalls some highlights in the history of lambda research, and relates how simple (but elegant) experiments yielded major scientific breakthroughs. What we know about recombination, gene regulation, and protein folding, for example, derives in large part from bacteriophage lambda genetics. Lambda not only represents a model system of scientific logic in a technology-driven age, but continues to reveal new principles of molecular biology.
对λ噬菌体的研究为深入了解基本生物学过程提供了关键见解。本综述回顾了λ噬菌体研究历史中的一些亮点，并阐述了简单（却精妙）的实验如何带来重大科学突破。例如，我们对重组、基因调控和蛋白质折叠的认识，很大程度上源自λ噬菌体遗传学。λ噬菌体不仅是技术驱动时代科学逻辑的一个模型系统，而且仍在不断揭示分子生物学的新原理。
