维甲酸受体-β表达缺失是食管癌发生过程中的早期事件。
Loss of retinoic acid receptor-beta expression is an early event during esophageal carcinogenesis.
作者信息
Qiu H, Zhang W, El-Naggar A K, Lippman S M, Lin P, Lotan R, Xu X C
机构信息
Departments of Clinical Cancer Prevention, Thoracic/Head and Neck Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
出版信息
Am J Pathol. 1999 Nov;155(5):1519-23. doi: 10.1016/s0002-9440(10)65467-3.
We recently observed that growth inhibition of esophageal cancer cells by retinoic acid (RA) was associated with both constitutive expression and RA-induced up-regulation of RA receptor beta (RAR-beta). Cell lines that did not express RAR-beta were also resistant to RA. To explore the expression of RAR-beta mRNA in vivo, we analyzed esophageal tissue specimens from 16 normal mucosae, 30 dysplastic lesions, and 157 esophageal tumors by in situ hybridization. RAR-beta was detected in 88% (14/16) of normal esophageal tissues and in 96% (96/100) of distant normal esophageal mucosa from cancer specimens. In contrast, RAR-beta was expressed in only 57% (17/30) of dysplastic lesions and in 54% (84/157) of carcinomas. Among esophageal carcinomas RAR-beta mRNA was expressed in 62% (26/42) of well-differentiated, 54% (27/50) of moderately differentiated, and only 29% (4/14) of poorly differentiated SCCs. Our data suggest that the loss of RAR-beta expression is an early event associated with esophageal carcinogenesis and the status of squamous differentiation.
我们最近观察到，维甲酸（RA）对食管癌细胞的生长抑制作用与RA受体β（RAR-β）的组成性表达及RA诱导的上调均相关。不表达RAR-β的细胞系对RA也具有抗性。为了探究RAR-β mRNA在体内的表达情况，我们通过原位杂交分析了16份正常黏膜、30份发育异常病变组织及157份食管肿瘤的食管组织标本。在88%（14/16）的正常食管组织及96%（96/100）的远离癌标本的正常食管黏膜中检测到RAR-β。相比之下，RAR-β仅在57%（17/30）的发育异常病变组织及54%（84/157）的癌组织中表达。在食管癌中，RAR-β mRNA在62%（26/42）的高分化鳞状细胞癌、54%（27/50）的中分化鳞状细胞癌及仅29%（4/14）的低分化鳞状细胞癌中表达。我们的数据表明，RAR-β表达缺失是与食管癌变及鳞状分化状态相关的早期事件。
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