Leverkus M, Rose C, Bröcker E B, Hamm H
Klinik für Haut- und Geschlechtskrankheiten der Universität Würzburg.
Hautarzt. 1999 Oct;50(10):733-8. doi: 10.1007/s001050051059.
A 69-year-old woman presented with widespread symmetrical papular lesions in submammary and inguinal areas. History revealed that the disease had only been present for a few years. A skin biopsy showed focal suprabasal acantholysis, dyskeratosis up to the horny layer and in part parakeratotic hyperkeratosis. The patient had no further evidence for Darier disease, Hailey-Hailey disease or pemphigus vegetans. In particular, characteristic lesions of Darier disease of hands and nails were absent. We found several reports in the literature describing similar skin lesions in intertriginous and genital areas with histological evidence of acantholytic dyskeratosis under various terms. This report discusses the difference between these cases and the differential diagnoses, in particular Darier disease. We propose to designate cases of intertriginous papulosis with histological proof of acantholytic dyskeratosis but without further evidence of Darier disease as intertriginous acantholytic dyskeratosis.
一名69岁女性患者，在乳房下和腹股沟区域出现广泛对称的丘疹性病变。病史显示该疾病仅存在数年。皮肤活检显示局灶性基底层上棘层松解、角质层直至角质层的角化不良以及部分角化不全性角化过度。患者没有进一步的证据支持毛囊角化病、黑棘皮病或增殖性天疱疮。特别是，手部和指甲没有毛囊角化病的特征性病变。我们在文献中发现了几篇报道，描述了在摩擦部位和生殖器区域出现类似皮肤病变，并伴有棘层松解性角化不良的组织学证据，这些报道使用了各种术语。本报告讨论了这些病例与鉴别诊断之间的差异，特别是毛囊角化病。我们建议将具有棘层松解性角化不良组织学证据但无毛囊角化病进一步证据的摩擦部位丘疹病病例命名为摩擦部位棘层松解性角化不良。
