Açikgöz B, Akpinar G, Bingöl N, Usseli I
Department of Neurosurgery, Bayindir Medical Center, Ankara, Turkey.
Acta Neurochir (Wien). 1999;141(10):1095-9. doi: 10.1007/s007010050489.
Hydrocephalus is known to cause various endocrinological abnormalities. These abnormalities are either though a direct effect on anterior hypothalamus or pituitary gland. However almost nothing is known about the effects of hydrocephalus on the intrinsic angiotensin system of the brain. The aim of this study is to investigate the effect of hydrocephalus on neurotransmitter-rich circumventricular organ systems. Such an effect was investigated by means of angiotensin receptor content in subfornical organ (SFO), organum vasculosum lamina terminalis (OVLT), area postrema (AP) and the median eminence (ME). Experimental hydrocephalus was created in rats by the intracisternal kaolin injection method as described by Shapiro et al. The receptor content was measured at 4-6 weeks by in-vitro autoradiography method as described by Israel et al. Angiotensin II receptor content in hydrocephalic animals was found to be statistically increased in SFO, OVLT and ME but not in AP when compared with the normal animals. Receptor content was found to have increased by 182.4% at SFO, 76.7% at ME, 7.7% at AP and 22.1% at OVLT after kaolin injection. These findings may indicate the possible role of CVO's on pathological conditions such as hydrocephalus.
脑积水已知会导致各种内分泌异常。这些异常要么是通过对下丘脑前部或垂体的直接作用引起的。然而，关于脑积水对大脑内在血管紧张素系统的影响几乎一无所知。本研究的目的是调查脑积水对富含神经递质的室周器官系统的影响。通过穹窿下器官（SFO）、终板血管器（OVLT）、最后区（AP）和正中隆起（ME）中的血管紧张素受体含量来研究这种影响。如Shapiro等人所述，通过脑池内注射高岭土的方法在大鼠中制造实验性脑积水。如Israel等人所述，在4 - 6周时通过体外放射自显影法测量受体含量。与正常动物相比，脑积水动物的SFO、OVLT和ME中的血管紧张素II受体含量在统计学上增加，而AP中没有增加。高岭土注射后，SFO的受体含量增加了182.4%，ME增加了76.7%，AP增加了7.7%，OVLT增加了22.1%。这些发现可能表明室周器官在脑积水等病理状况中可能发挥的作用。
