Lekic Tim, Klebe Damon, Poblete Roy, Krafft Paul R, Rolland William B, Tang Jiping, Zhang John H
Department of Physiology and Pharmacology, Loma Linda University School of Medicine, 11041 Campus Street, Risley Hall Rm 219, Loma Linda, California, 92354, USA.
Curr Med Chem. 2015;22(10):1214-38. doi: 10.2174/0929867322666150114152421.
Neonatal brain hemorrhage (NBH) of prematurity is an unfortunate consequence of preterm birth. Complications result in shunt dependence and long-term structural changes such as posthemorrhagic hydrocephalus, periventricular leukomalacia, gliosis, and neurological dysfunction. Several animal models are available to study this condition, and many basic mechanisms, etiological factors, and outcome consequences, are becoming understood. NBH is an important clinical condition, of which treatment may potentially circumvent shunt complication, and improve functional recovery (cerebral palsy, and cognitive impairments). This review highlights key pathophysiological findings of the neonatal vascular-neural network in the context of molecular mechanisms targeting the posthemorrhagic hydrocephalus affecting this vulnerable infant population.
早产新生儿脑内出血（NBH）是早产带来的不幸后果。并发症会导致对分流术的依赖以及长期的结构改变，如出血后脑积水、脑室周围白质软化、胶质增生和神经功能障碍。有几种动物模型可用于研究这种病症，许多基本机制、病因因素和结局后果也逐渐为人所了解。NBH是一种重要的临床病症，其治疗可能会避免分流术并发症，并改善功能恢复（如脑瘫和认知障碍）。本综述重点介绍了新生儿血管神经网络在针对影响这一脆弱婴儿群体的出血后脑积水的分子机制背景下的关键病理生理学发现。
