Federico F, Simone I L, Lucivero V, Mezzapesa D M, de Mari M, Lamberti P, Petruzzellis M, Ferrari E
Department of Neurological and Psychiatric Sciences, University of Bari, Italy.
Ital J Neurol Sci. 1999 Aug;20(4):223-9. doi: 10.1007/s100720050035.
Proton magnetic resonance spectroscopy ((1)H-MRS) was performed in patients with a clinical diagnosis of idiopathic Parkinson's disease (IPD), multiple system atrophy (MSA) or progressive supranuclear palsy (PSP) in order to assess metabolic differences between the three groups of patients. Single-volume (1)H-MRS, localized to the lentiform nucleus, was carried out in 19 IPD patients, 14 MSA patients, 11 PSP patients and 12 age-matched healthy subjects. The signals of N-acetylaspartate (NAA), choline-containing compounds (Cho) and creatine-phosphocreatine (Cr) were evaluated as peak area ratios. The NAA/Cho peak ratio was significantly reduced in MSA and in PSP patients compared to IPD patients and to controls. The NAA/Cr peak ratio was significantly reduced in MSA, in PSP and in IPD patients compared to controls, but only in MSA compared to IPD patients. The NAA reduction in the basal ganglia of MSA and PSP patients may reflect a neuronal loss or damage. Single-volume (1)H-MRS may be a useful tool in differentiating MSA and PSP from IPD patients.
对临床诊断为特发性帕金森病（IPD）、多系统萎缩（MSA）或进行性核上性麻痹（PSP）的患者进行质子磁共振波谱分析（（1）H-MRS），以评估三组患者之间的代谢差异。对19例IPD患者、14例MSA患者、11例PSP患者和12例年龄匹配的健康受试者进行了定位于豆状核的单容积（1）H-MRS。将N-乙酰天门冬氨酸（NAA）、含胆碱化合物（Cho）和肌酸-磷酸肌酸（Cr）的信号评估为峰面积比。与IPD患者和对照组相比，MSA和PSP患者的NAA/Cho峰比显著降低。与对照组相比，MSA、PSP和IPD患者的NAA/Cr峰比显著降低，但仅MSA与IPD患者相比降低。MSA和PSP患者基底节区NAA的降低可能反映神经元丢失或损伤。单容积（1）H-MRS可能是区分MSA和PSP与IPD患者的有用工具。
