Heim Beatrice, Krismer Florian, De Marzi Roberto, Seppi Klaus
Department of Neurology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria.
Neuroimaging Research Core Facility, Medical University Innsbruck, Innsbruck, Austria.
J Neural Transm (Vienna). 2017 Aug;124(8):915-964. doi: 10.1007/s00702-017-1717-8. Epub 2017 Apr 4.
The differential diagnosis of parkinsonian syndromes is considered one of the most challenging in neurology and error rates in the clinical diagnosis can be high even at specialized centres. Despite several limitations, magnetic resonance imaging (MRI) has undoubtedly enhanced the diagnostic accuracy in the differential diagnosis of neurodegenerative parkinsonism over the last three decades. This review aims to summarize research findings regarding the value of the different MRI techniques, including advanced sequences at high- and ultra-high-field MRI and modern image analysis algorithms, in the diagnostic work-up of Parkinson's disease. This includes not only the exclusion of alternative diagnoses for Parkinson's disease such as symptomatic parkinsonism and atypical parkinsonism, but also the diagnosis of early, new onset, and even prodromal Parkinson's disease.
帕金森综合征的鉴别诊断被认为是神经病学中最具挑战性的任务之一，即使在专业中心，临床诊断的错误率也可能很高。尽管存在一些局限性，但在过去三十年中，磁共振成像（MRI）无疑提高了神经退行性帕金森病鉴别诊断的准确性。本综述旨在总结有关不同MRI技术价值的研究结果，包括高场和超高场MRI的先进序列以及现代图像分析算法，用于帕金森病的诊断检查。这不仅包括排除帕金森病的替代诊断，如症状性帕金森综合征和非典型帕金森综合征，还包括早期、新发甚至前驱期帕金森病的诊断。
