兔视觉皮层感受野的发育：因睁眼延迟导致的时间进程变化。
Development of receptive fields in rabbit visual cortex: changes in time course due to delayed eye-opening.
作者信息
Grobstein P, Chow K L, Fox P C
出版信息
Proc Natl Acad Sci U S A. 1975 Apr;72(4):1543-5. doi: 10.1073/pnas.72.4.1543.
Rabbit pups had one eye sutured closed before the time at which the eyes normally open. At 20-27 days of age, single-unit recordings were made both from the striate cortex contralateral to the sutured eye (deprived cortex) and from that contralateral to the eye which had opened normally (control cortex). The percentages of units encountered which fell into various receptive field categories differed on the two sides. The deprived cortices had a lower percentage of visually responsive cells, a higher percentage of indefinite cells, and totally lacked cells sensitive to orientation of a stimulus bar. In these respects they closely resembled previous observations on rabbit pups just before normal eye-opening. By contrast, the control cortices of the same animals were comparable to normally reared rabbits of the same age. We conclude, therefore, that developmental events which normally follow eye-opening can be affected in their time course by delaying eye-opening.
兔崽在眼睛正常睁开的时间之前，将一只眼睛缝合闭合。在20至27日龄时，对缝合眼对侧的纹状皮层（剥夺皮层）和正常睁开眼对侧的纹状皮层（对照皮层）进行单神经元记录。在两侧，归入各种感受野类别的神经元百分比有所不同。剥夺皮层中视觉反应细胞的百分比更低，不确定细胞的百分比更高，并且完全缺乏对刺激棒方向敏感的细胞。在这些方面，它们与之前对即将正常睁眼的兔崽的观察结果非常相似。相比之下，同一动物的对照皮层与相同年龄正常饲养的兔子相当。因此，我们得出结论，正常情况下在睁眼后发生的发育事件，其时间进程会因延迟睁眼而受到影响。
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