Kratz K E, Spear P D
J Comp Neurol. 1976 Nov 15;170(2):141-51. doi: 10.1002/cne.901700202.
Electrophysiological recordings were made from single neurons in striate cortex of normally reared kittens (group N), kittens raised with binocular lid-suture (group BD), and kittens raised with one eye lid-sutured and other eye removed (group MD-E). The MD-E group represents a condition in which inputs from the deprived eye have been placed at a competitive advantage over those from the other eye. In agreement with previous studies, fewer cells were responsive to visual stimulation in BD kittens than in N kittens. Among the responsive cells, fewer were direction selective, fewer were orientation selective, and more had inconsistent or fast-adapting responses than in normals. The responsiveness and receptive field properties of striate cortex neurons in the MD-E kittens were less affected by the visual deprivation than in BD kittens; however, they still were abnormal in comparison to normal kittens. Comparison of the ocular dominance distributions for cells in N and BD kittens showed a marked reduction in binocularly driven cells in BD kittens. In addition, in BD kittens, a larger proportion of monocularly driven cells had orientation selective receptive fields than did binocularly driven cells. This difference was not found in normally reared kittens. The results of this study suggest that abnormal binocular interactions contribute to the effects of visual deprivation following binocular lid-suture, probably due to asynchronous light-dark inputs through the closed lids. Removing the other eye and placing inputs from the deprived eye at a competitive advantage during development results in decreased effects on striate cortex neurons. Nevertheless, visual deprivation still produces abnormalities in striate cortex independent of asynchronous or uncorrelated visual stimulation of the two eyes.
对正常饲养的小猫（N组）、双眼睑缝合饲养的小猫（BD组）以及一只眼睑缝合而另一只眼被摘除饲养的小猫（MD-E组）的纹状皮层单个神经元进行电生理记录。MD-E组代表一种情况，即来自剥夺眼的输入相对于来自另一只眼的输入具有竞争优势。与先前的研究一致，BD组小猫中对视觉刺激有反应的细胞比N组小猫少。在有反应的细胞中，方向选择性细胞较少，取向选择性细胞较少，且与正常小猫相比，具有不一致或快速适应反应的细胞更多。MD-E组小猫纹状皮层神经元的反应性和感受野特性受视觉剥夺的影响比BD组小猫小；然而，与正常小猫相比，它们仍然是异常的。对N组和BD组小猫细胞的眼优势分布进行比较，结果显示BD组小猫中双眼驱动细胞明显减少。此外，在BD组小猫中，单眼驱动细胞中具有取向选择性感受野的比例比双眼驱动细胞大。在正常饲养的小猫中未发现这种差异。本研究结果表明，异常的双眼相互作用导致了双眼睑缝合后视觉剥夺的影响，这可能是由于通过闭合眼睑的明暗输入不同步所致。在发育过程中摘除另一只眼并使来自剥夺眼的输入具有竞争优势，会减少对纹状皮层神经元的影响。然而，视觉剥夺仍然会在纹状皮层产生异常，这与双眼的异步或不相关视觉刺激无关。
