Onoda N, Kobayashi H, Satake K, Ishikawa T, Maeda K, Chung K H, Kitada T, Seki S, Wakasa K
First Department of Surgery, Institute of Geriatrics and Medical Science, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno.ku, Osaka 545-8585, Japan.
Surg Today. 1999;29(10):1079-82. doi: 10.1007/s005950050648.
Neuroendocrine carcinoma of the colon is a rare entity; however, this type of tumor is known for its aggressive progression and poor prognosis. A case of a 56-year-old Japanese male is presented in this report. A huge, child's head-sized tumor was found to have grown extraluminally on the sigmoid colon with multiple liver metastases. The tumor measured 16.5 x 15 x 8.2 cm in size and weighed 1 300 g. The patient died of hepatic failure due to massive liver metastases 6 months after operation. The pathological findings including an electron microscopic analysis were correlated with those of neuroendocrine carcinoma. We reviewed the English literature, and analyzed 94 cases of neuroendocrine carcinoma which had been reported previously. The nomenclature and definition of this disease still remains somewhat unclear, and not a small population of this disease may thus have been misdiagnosed and treated as other less aggressive entities. The necessity to make an accurate differential diagnosis in such cases is thus emphasized.
结肠神经内分泌癌是一种罕见的疾病；然而，这种类型的肿瘤以其侵袭性进展和不良预后而闻名。本报告介绍了一例56岁的日本男性病例。发现一个巨大的、有儿童头部大小的肿瘤在乙状结肠腔外生长，并伴有多处肝转移。肿瘤大小为16.5×15×8.2厘米，重1300克。患者术后6个月因大量肝转移死于肝功能衰竭。包括电子显微镜分析在内的病理结果与神经内分泌癌的结果相关。我们回顾了英文文献，并分析了先前报道的94例神经内分泌癌病例。这种疾病的命名和定义仍然有些不清楚，因此可能有不少这类疾病被误诊并当作其他侵袭性较小的疾病进行治疗。因此强调了在此类病例中进行准确鉴别诊断的必要性。
