Vilor M, Tsutsumi Y, Osamura R Y, Tokunaga N, Soeda J, Ohta M, Nakazaki H, Shibayama Y, Ueno F
Department of Pathology, Tokai University School of Medicine, Isehara, Japan.
Pathol Int. 1995 Aug;45(8):605-9. doi: 10.1111/j.1440-1827.1995.tb03510.x.
Poorly differentiated small cell neuroendocrine (NE) carcinoma of the colon and rectum is a rare primary epithelial malignancy at this location. A case of a highly aggressive NE tumor of small cell type, combined with non-invasive well-differentiated papillary adenocarcinoma in villous adenoma is reported. The patient died rapidly with massive and progressive liver metastasis. The tumor cells were argyrophilic and diffusely immunoreactive for neuronspecific enolase and synaptophysin. Ultrastructural analysis disclosed NE-type cored granules in most of the small tumor cells. NE tumors of the colon and rectum are briefly reviewed.
结肠和直肠低分化小细胞神经内分泌（NE）癌是该部位罕见的原发性上皮恶性肿瘤。本文报告了一例小细胞型高侵袭性NE肿瘤，合并绒毛状腺瘤中的非侵袭性高分化乳头状腺癌。患者因大量进行性肝转移迅速死亡。肿瘤细胞嗜银，对神经元特异性烯醇化酶和突触素呈弥漫性免疫反应。超微结构分析显示大多数小肿瘤细胞中有NE型核心颗粒。对结肠和直肠的NE肿瘤进行了简要综述。
