von Gagern G, Zimmermann T, Albrecht S, Bachmann L, Zwipp H, Saeger H D
Klinik und Poliklinik für Viszeral-, Thorax- und Gefässchirurgie, Universitätsklinikum Carl Gustav Carus, TU Dresden.
Med Klin (Munich). 1999 Oct 15;94 Suppl 3:62-5. doi: 10.1007/BF03042195.
The authors have investigated the relationship between selenium and transcription factors (NF-kappa B and AP-1) in the field of pathogenesis of polytrauma. Correlations between plasma selenium content and transcription factor binding activity have been found. The measured connecting capacitances of transcription factors have been associated with the severity of disease. To harden the results of this research a randomized double blind study with sodium selenite substitution is necessary next. This study will be to establish the therapy with sodium selenite in the treatment of polytrauma.
