Miyauchi E, Matsumoto M, Kimura Y, Hattori H, Tsukio Y, Tsuchiya H, Takasaki M, Munehira J, Yamada K, Iwai K, Kawanishi K, Hoshino T, Murai H
Department of Geriatric Medicine, Kanazawa Medical University.
Nihon Ronen Igakkai Zasshi. 1999 Aug;36(8):542-6. doi: 10.3143/geriatrics.36.542.
Arotinolol hydrochloride with alpha-and beta-receptor blocking action, developed in Japan, is mainly used for the treatment of hypertension. The study population consisted of 42 outpatients with essential hypertension with a blood pressure greater or equal to 160/96 mmHg. 10 men and 32 women, with a mean age of 77.5 year. The patients received 10 mg arotinolol hydrochloride daily for 24 weeks which was taken orally twice a day. We evaluated the changes of blood pressure, heart rate and chief complaints of patients before and every 4 weeks during treatment and the renal function before, 12 weeks after and 24 weeks after, the administration of arotinolol hydrochloride. Blood pressure and heart rate decreased significantly after 4 weeks of treatment with arotinolol hydrochloride (p < 0.05). However, no significant changes were found in blood urea nitrogen, serum creatinine, serum albumin, beta2-microglobuline, NAG or creatinine clearance during the 24 weeks of treatment. These results indicate that arotinolol hydrochloride has antihypertensive effects without renal dysfunction in elderly patients with essential hypertension.
盐酸阿罗洛尔具有α和β受体阻滞作用，由日本研发，主要用于治疗高血压。研究对象包括42例原发性高血压门诊患者，血压≥160/96 mmHg。其中男性10例，女性32例，平均年龄77.5岁。患者每日口服10 mg盐酸阿罗洛尔，共24周，分两次服用。我们评估了治疗前、治疗期间每4周患者的血压、心率和主要症状变化，以及服用盐酸阿罗洛尔前、服药12周后和24周后的肾功能。盐酸阿罗洛尔治疗4周后血压和心率显著下降（p<0.05）。然而，在24周的治疗期间，血尿素氮、血清肌酐、血清白蛋白、β2-微球蛋白、NAG或肌酐清除率均未发现显著变化。这些结果表明，盐酸阿罗洛尔对老年原发性高血压患者有降压作用且无肾功能损害。
