Majkowska L
Kliniki Endokrynologii, Nadciśnienia Tetniczego i Chorób Przemiany Materii Pomorska Akademia Medyczna, Szczecin.
Przegl Lek. 1999;56(5):351-6.
Insulin resistance is a characteristic feature of different physiological states including puberty, pregnancy, elderly and is associated with numerous common medical disorders as obesity, diabetes mellitus type 2, hyperlipidaemia, essential hypertension. Tests used for estimation of insulin sensitivity in vivo can be divided into indirect tests measuring action of endogenous insulin, usually in response to a glucose stimulus, and direct tests measuring glucose metabolism in response to exogenous insulin. Indirect tests--oral glucose tolerance test, intravenous glucose tolerance test, minimal Bergmans method, continuous infusion of glucose with model assessment (CIGMA), hyperglycemic clamp and direct tests--intravenous insulin tolerance test, insulin suppression test, euglycemic clamp are described, and their advantages and disadvantages are discussed.
胰岛素抵抗是包括青春期、妊娠、老年在内的不同生理状态的一个特征，并且与许多常见的医学病症相关，如肥胖症、2型糖尿病、高脂血症、原发性高血压。用于体内胰岛素敏感性评估的测试可分为间接测试和直接测试，间接测试通常是测量内源性胰岛素对葡萄糖刺激的反应作用，直接测试则是测量对外源性胰岛素的葡萄糖代谢反应。文中描述了间接测试——口服葡萄糖耐量试验、静脉葡萄糖耐量试验、改良的伯格曼法、葡萄糖持续输注模型评估（CIGMA）、高血糖钳夹试验，以及直接测试——静脉胰岛素耐量试验、胰岛素抑制试验、正常血糖钳夹试验，并讨论了它们的优缺点。
