Idzior-Waluś B
Katedry i Kliniki Chorób Metabolicznych Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie.
Przegl Lek. 1999;56(5):372-6.
In this paper the results of recently published primary and secondary prevention trials of coronary heart disease using statins are presented. Statins are effective in patients with high and mean serum cholesterol levels, in elderly patients in men and in women. The IAS Expert Group recommendations concerning hyperlipidemia treatment in coronary heart disease prevention are presented. Lowering LDL-cholesterol, the most atherogenic lipoprotein fraction is a goal of the treatment and LDL-cholesterol level is recommended for monitoring of efficacy of the treatment. Hypertriglyceridemia (1.7-4.5 mmol/l) is a coronary heart disease risk factor, however the role of triglyceride lowering in coronary heart disease prevention remains to be established by clinical trials. Assessment and treatment of all coronary risk factors is essential for prevention.
本文介绍了近期发表的使用他汀类药物进行冠心病一级和二级预防试验的结果。他汀类药物对血清胆固醇水平高和中等的患者、老年男性和女性均有效。文中还介绍了国际动脉粥样硬化学会（IAS）专家组关于冠心病预防中高脂血症治疗的建议。降低低密度脂蛋白胆固醇（LDL-C）这一最具致动脉粥样硬化作用的脂蛋白组分是治疗目标，建议通过监测LDL-C水平来评估治疗效果。高甘油三酯血症（1.7 - 4.5 mmol/l）是冠心病的危险因素，然而降低甘油三酯在冠心病预防中的作用仍有待临床试验确定。评估和治疗所有冠心病危险因素对于预防至关重要。
