Zagozdzon R, Ziółkowski J, Paczek L
Kliniki Immunoterapii Chorób Wewnetrznych, Akademia Medyczna w Warszawie.
Przegl Lek. 1999;56(5):390-3.
Autoimmune hepatis along with primary biliary cirrhosis, primary sclerosing cholagitis and some other not classified primary hepatobiliary pathologies belong to the group of liver diseases which are believed to be caused by autoimmune reactions. The primary causes of those pathological states remain unknown. However, thanks to the recent studies in immunogenetics and on autoantigens, progress has been made in understanding the mechanisms underlying these pathologies. The results of these studies are criteria of diagnosis and treatment of those diseases. In spite of some beneficial results of immunosuppressive treatment of AIH, the disease in some cases progresses and those states are one of the classical indications for allogenic liver transplantation.
自身免疫性肝炎与原发性胆汁性肝硬化、原发性硬化性胆管炎以及其他一些未分类的原发性肝胆疾病属于一类被认为由自身免疫反应引起的肝脏疾病。这些病理状态的主要病因尚不清楚。然而，由于最近在免疫遗传学和自身抗原方面的研究，在理解这些疾病的发病机制方面取得了进展。这些研究结果是这些疾病诊断和治疗的标准。尽管免疫抑制治疗自身免疫性肝炎取得了一些有益的结果，但在某些情况下疾病仍会进展，而这些情况是同种异体肝移植的经典指征之一。
